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Cell Signaling and Carcinogenesis
The Williams Laboratory is interested in understanding how alterations in the Wnt signaling pathway cause human disease. Wnt signaling is an evolutionarily conserved process that functions in the differentiation of most tissues within the body.
News
Fall 2014 Prostate cancer research at Van Andel Research Institute (VARI): A multi-faceted approach
Prostate Cancer Communication
22 Jan. 2013 Wells Fargo Foundation announces grant for Van Andel Institute study
Recent Publications
Ubels JL et al. Structure and function of the retina of low-density lipoprotein receptor-related protein 5 (Lrp5)-deficient rats . Exp Eye Res.
Chen J et al. Disruption of tubular FLCN expression as a mouse model for renal tumor induction. Kidney Int
Meng X et al. Myeloid-specific TGF-b signaling in bone promotes basic-FGF and breast cancer bone metastasis. Oncogene
Oursler MJ et al. Response to Wnt signaling pathways. J Bone Miner Res
Weivoda MM et al. Wnt signaling inhibits osteoclast differentiation by activating canonical and non-canonical cAMP/PKA pathways. J Bone Miner Res